Cytokines,exemplified by interleukins, exert their therapeutic effects by binding to cognate receptors on diverse immune cells, thereby modulating immunity to treat disease. However, native cytokines are limited by low molecular weight, short half-life, and toxicity-driven narrow therapeutic windows, all of which hinder their clinical translation.
To develop fully optimized cytokine fusion proteins, Forlong Biotech has built four integrated core platforms:
Fbody ® Long-acting Technology Platform
Extend the cytokine half-life
No Fc effect,improved safety
Smaller molecular weight for improved tumor penetration and drug distribution
Fc engineering platform
Tunable effector functions (ADCC, ADCP, etc.)
Enable drug targeting capabilities
Intelligent Biomolecular Discovery Platform
Assist design and generation of cytokines and fusion proteins
Assist discovery and optimization of antibodies
Assist optimization of fusion protein properties
Syntokine® Synthetic Cytokine Platform
Pinpoint critical cytokine-receptor interaction sites
High-throughput screening based on multiple library combinations
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